Inhibition of chemotaxis induced with mixtures of chemokines by MAb d5d7.

<p>Inhibition of chemotaxis of (<b>A</b>) CCR5 transfectants to a pool of recombinant CCL3, CCL4, and CCL5 and (<b>B</b>) CCR1 transfectants to a pool of CCL3 and CCL5, by MAb d5d7 antibody, vCCI-Fc, individual commercial anti-chemokine antibodies (anti-CCL3, anti-CCL4, and anti-CCL5), and IgG controls. Chosen chemokine concentrations were those that produced 50% maximal chemotaxis when tested individually (a pool of 3 ng/mL CCL3, 10 ng/mL CCL4, and 3 ng/mL CCL5 was used in CCR5 experiments and a mixture of 20 ng/mL CCL3 and 5 ng/mL CCL5 was used in CCR1 experiments).