Effect of metformin treatment (300 mg/kg/day, two weeks) on the number of total inflammatory cells (A) and eosinophils (B) in lung connective tissue surrounding the bronchial and bronchiolar segments at 48 h following intranasal challenge with ovalbumin in the sensitized mice.

<p>Representative high-power fields of bronchiolar structures from the following groups: mice sensitized lean treated with vehicle (SL), sensitized obese treated with vehicle (SO), sensitized lean treated with metformin (SL + Met) and sensitized obese treated with metformin (SO + Met). Panel C shows representative images of lung histology for the four experimental groups. Haematoxylin–eosin, high magnification (bar represents 20 µm). Each column represents mean ± SEM (n = 6) of the number of cells mm². *p<0.05.