Effect of monoclonal anti-TNF-α antibody treatment (2 mg/kg) on the number of total inflammatory cells (A) and eosinophils (B) in lung connective tissue surrounding the bronchial and bronchiolar segments at 48 h following intranasal challenge with ovalbumin in sensitized mice.

<p>Anti-TNF-α antibody was given intraperitoneally at days 14 and 15 and 1 h before the first ovalbumin challenge. Representative high-power fields of bronchiolar structures from the following groups: sensitized lean (SL), sensitized obese (SO), sensitized lean treated with anti-TNF-α (SL + anti-TNF-α) and sensitized obese treated with anti-TNF-α (SO + anti-TNF-α). Panel C shows representative images of lung histology for the four experimental groups. Each column represents mean ± SEM (n = 6) of the number of cells mm². Haematoxylin–eosin, high magnification (bar represents 20 µm). *p<0.05.