<p>Cytocochleograms indicate percentage of outer (OHC) and inner (IHC) hair-cell loss as a function of percent distance from the cochlear apex, where 0% distance describes the most apical region of the cochlea and 100% distance describes the most basal region of the cochlea, excluding the cochlear hook. Hair-cell loss is shown for three-week-old <i>trhl</i> homozygotes (n = 5) (<b>A</b>) and heterozygotes (n = 5) (<b>B</b>) and for seven-week-old <i>trhl</i> homozygotes (n = 5) (<b>C</b>) and heterozygotes (n = 5) (<b>D</b>). Data points represent the mean percentage, with error bars indicating standard deviation. There is clear evidence of hair-cell loss to a much greater degree in the homozygous mutants as compared to the heterozygous con...
<p>(A) There was no significant difference in temporal bones between mutant and wild-type mice at P1...
ABR thresholds of Klc2 mutants are close to those of controls at 2 weeks old, and show significant, ...
<p>Example photomicrographs of surface preparations of the basal turn of the cochlea from (A) normal...
<p>The number of hair cells in each row per 200 µm was collected at the apex, mid and base in P0 coc...
<p>Representative cochlear sections from<i>Atoh1<sup>trhl/trhl</sup></i>and control <i>Atoh1<sup>trh...
<p>Cochleas were stained with phalloidin, which binds to filamentous actin (red) and anti-prestin an...
<p>Ultrastructural analysis using scanning electron microscopy of cochlear hair cells in <i>Synj2</i...
<p>(A) Scanning electron microscopy (SEM) views of the cochlea at P8: an overview of the apical turn...
<div><p>Lectin staining of whole-mount cochlea at E16.5.</p><p>(A) Normal patterning in wild-type co...
<div><p>Scanning electron micrographs demonstrating the different patterns of hair cell production a...
<p>Middle cochlear turn sections at 8 weeks of age; Upper panels 100x magnification, scale bar 200 µ...
Lated from animals with the genotypes specified (). The percent of the number of hair cells in extra...
<p>Confocal whole-mount images of cochlea in the control and LKB1 mutant cochlea at P21. Hair cells ...
<p>SEM images showing stereocilial bundles of outer hair cells in the mid-basal turn in wild-type at...
<p>A–C) Although the stereocilia bundles were disorganized at the apical turn of the cochlea, the ha...
<p>(A) There was no significant difference in temporal bones between mutant and wild-type mice at P1...
ABR thresholds of Klc2 mutants are close to those of controls at 2 weeks old, and show significant, ...
<p>Example photomicrographs of surface preparations of the basal turn of the cochlea from (A) normal...
<p>The number of hair cells in each row per 200 µm was collected at the apex, mid and base in P0 coc...
<p>Representative cochlear sections from<i>Atoh1<sup>trhl/trhl</sup></i>and control <i>Atoh1<sup>trh...
<p>Cochleas were stained with phalloidin, which binds to filamentous actin (red) and anti-prestin an...
<p>Ultrastructural analysis using scanning electron microscopy of cochlear hair cells in <i>Synj2</i...
<p>(A) Scanning electron microscopy (SEM) views of the cochlea at P8: an overview of the apical turn...
<div><p>Lectin staining of whole-mount cochlea at E16.5.</p><p>(A) Normal patterning in wild-type co...
<div><p>Scanning electron micrographs demonstrating the different patterns of hair cell production a...
<p>Middle cochlear turn sections at 8 weeks of age; Upper panels 100x magnification, scale bar 200 µ...
Lated from animals with the genotypes specified (). The percent of the number of hair cells in extra...
<p>Confocal whole-mount images of cochlea in the control and LKB1 mutant cochlea at P21. Hair cells ...
<p>SEM images showing stereocilial bundles of outer hair cells in the mid-basal turn in wild-type at...
<p>A–C) Although the stereocilia bundles were disorganized at the apical turn of the cochlea, the ha...
<p>(A) There was no significant difference in temporal bones between mutant and wild-type mice at P1...
ABR thresholds of Klc2 mutants are close to those of controls at 2 weeks old, and show significant, ...
<p>Example photomicrographs of surface preparations of the basal turn of the cochlea from (A) normal...