Hair Cell Patterning Defects in the Cochlea

<div><p>Scanning electron micrographs demonstrating the different patterns of hair cell production along the length of the cochlea in <i>Jag1-cko</i> embryos.</p><p>(A–D) Low-power views of the apical and basal cochlear turns. The boxed-in area along the base in (A) and (B) is shown at higher magnification in (C) and (D). Note the absence of hair cells in the base of the <i>Jag1-cko</i> cochlea, except for a small patch of cells in the more apical portion (arrow). Scale bars = 500 μm.</p><p>(E and F) In the midbasal region, more hair cells are observed, but they are arranged in patches, with no clear distinction between inner and outer hair cells.</p><p>(G and H) In the apical turn, hair cells are continuous but generally arranged in only two rows. Scale bar = 100 μm.</p>