Mutations in where repacking residues nearby the mutation improves the prediction compared to minimization alone.

<p>In each case the mutant structure refined by minimization is shown in cyan and the mutant structure where a 5A radius was refined by side-chain prediction is shown in brown. The mutation residue is shown in ball-and-stick. Panel A shows the C:Thr170Ala mutation in 1AHW along with nearby residues. Panels B and C show the C:Trp43Ala mutation in 1FCC.