Curcumin diet causes clustering of biological replicates by changing B78H1 melanoma miRNA signature.

<p>Clustering of male C57BL/6 mice fed for 6 weeks either curcumin diet or control diet based on miRNA expression levels in the B78H1 melanoma. This diagram is based on 50 miRNAs with the highest variance across all samples. MiRNA expression variation is represented by different colors (see <i>color key</i>). Complete linkage hierarchical clustering was performed using the Euclidian distance to calculate the dissimilarity of miRNA and samples independently of one another. Clustering of samples is illustrated by upper dendrogram, clustering of miRNAs by the left dendrogram. Note that, based on the evaluated C57BL/6 mice, control and curcumin animals clearly divide into two main clusters.