Pathways putatively regulated by curcumin-altered miRNAs as found by over-representation analysis.

<p>Listed are pathways being putatively regulated by miRNAs of B78H1 melanoma which are altered by curcumin diet, as found by over-representation analysis with the online analysis-tool <i>GeneTrail</i>. As test sets we used the predicted targets of differentially regulated miRNAs and as reference set the putative targets of all murine miRNAs printed on the microarray. <i>GeneTrail</i> exhibited a search in disease-relevant cellular pathways as found in the Kyoto Encyclopedia of Genes and Genomes (KEGG) for enrichment of putative targets. MiRNAs up-regulated by curcumin diet (upper part of table) were separately tested from down-regulated miRNAs (lower part of table). The expected number of target genes, modulated in a pathway, is shown as well as the observed ones, including the according <i>P</i>-value and x-fold enrichment of targets.