Altered energy metabolite levels in <i>Npc1</i>^-/- cerebellum.

<p>Aqueous extracts of the cerebella from 3-, 4-, 5-, or 7-week old wildtype (WT) and <i>Npc1</i>^-/- mice were analyzed by ¹H-NMR spectroscopy. Spectra were deconvolved and integrated. Peak areas were standardized to total peak area. NAA: N-acetylaspartate. Inosit: myo-Inositol. Graphs in each column show data from the same set of WT and <i>Npc1</i>^-/- mice of one age. The small numbers inside the bars for lactate indicate the number of mice in each group. Data are expressed as percent of the average of WT samples of the same age. Shown are the mean ± SEM. * p<0.05, <i>Npc1</i>^-/- vs. WT.