Neurochemical profile of the hippocampus measured by single voxel ¹H MRS at 7 Tesla.

<p>A: Representative ¹H MR spectra acquired from the hippocampus of a 12-month-old wild-type mouse. B: Representative ¹H MR spectra acquired from the hippocampus of a 12-month-old AβPPswe-PS1dE9 transgenic mouse. Notice the decreased NAA peak in AβPP-PS1compared to wild-type. C: At 8 months of age, no differences between wild-type (n = 13) and AβPP-PS1 mice (n = 8) were observed in the hippocampal neurochemical profile. D: At 12 months of age, AβPP-PS1 mice (n = 4) had significantly lower concentrations of NAA than wild-type mice (n = 7), *<i>p</i><0.05. tCho = choline-containing compounds; tCre = creatine and phosphocreatine; Glu = glutamate; Glx = glutamine and glutamate; <i>m</i>I+Gly = <i>myo</i>-Inositol and glycine; NAA = <i>N</i>-acetylaspartate; Tau = taurine.