Overview of the alterations in gene and protein expression in <i>Npc1</i>^-/- cerebellum and the proposed effects on metabolic pathways.

<p>Schematics show glycolysis and pyruvate metabolism annotated with the mRNAs and proteins analyzed in this study in cerebellum from 3- or 5-week old WT and <i>Npc1</i>^-/- mice. Green squares: increased mRNA or protein levels. Red ovals: decreased mRNA or protein levels. No colour: unchanged mRNA or protein levels. PPP: pentose phosphate pathway. The grey shading represents the mitochondrial compartment. The proposed effects on the metabolic pathways are depicted by the thickness of the arrows.