Identification of FDH-I re-annotates 160 proteins.

<p>Proteins with sequences similar to the newly identified FDH-I were clustered based on their internal sequence similarities. Each node represents one of the protein sequences identified as homologous to fructose dehydrogenase from <i>Gluconobacter frateurii</i>; edges between nodes are drawn only if the similarity between a pair of sequences is better than an E-value threshold cutoff of 1e⁻⁶⁶. The network is visualized using the organic layout in Cytoscape. Nodes are colored according to assigned function in UniProtKB database; yellow: 2-keto-gluconate dehydrogenase, blue: choline dehydrogenase, cyan: fructose dehydrogenase from <i>Gluconobacter frateurii,</i> red: gluconate dehydrogenase, green: glucose-methanol-choline dehydrogenase. Large diamond shaped nodes with red borders are proteins that are used for identifying gene proximity clusters. Larger nodes are proteins with evidence of existence at the protein level.