Functional network of altered proteins present in both cell lines.

<p>ClueGO plugin of Cytoscape was used to generate a functional network (biological process). Node size is related to the degree (high degree represent important nodes in the network, also known as hubs) of the proteins and was calculated using the Cytoscape NetworkAnalyzer tool. Proteins node color is depicted as following (A549 vs SW900): green, proteins upregulated (fold-regulation > 2); red, proteins downregulated (fold-regulation > -2). Biological process node color is represented on the right side of the image. On the right bottom side of the image are shown the genes that does not fit these biological processes and that do not have any interaction with the proteins that are altered.