<p>Lungs were removed at 7 and 14 days after i.t. injection of PBS or 5×10<sup>5 </sup><i>H. capsulatum</i> yeast cells. TNF-α levels were determinate by ELISA. Data are presented as the mean ± SEM and are representative from one of two independent experiments (n = 6/each experiment). * 129/Sv compared with C57BL/6; <sup>#</sup>129/Sv <i>H. capsulatum</i> compared with C57BL/6 <i>H. capsulatum</i>. p<0.05 vs. PBS.</p
<p>BALB/c mice (seven/group) were infected with <i>P</i>. <i>brasiliensis yeast</i> (1x10<sup>6</sup...
<p>Male BALB/c mice (n = 5 mice/group for each analyses per experiment replicate) were inoculated wi...
<p>(A) Groups of 3–4 mice from the indicated strains were infected intranasally with 6,000 CFU of LV...
<p>Cells were obtained from mice at 7 and 14 days after i.t. injection of PBS or 5×10<sup>5 </sup><i...
<p>Amount of TNF-α in the lungs of 4–6 weeks (A) und 19 months (B) old BALB/c mice after infection w...
<p>WT and iNOS<sup>−/−</sup> mice (n = 6–7) were treated with anti-TNF-α mAb (MP6 XT 22, i.p. inject...
<p>IL12p70 (A), IFN-γ (B), TNF-α (C), IL-10 (D) and IL-4 (E) were quantified in 100 mg of lung homog...
<p>(<b>A, B</b>) At week 2 and 8 after i.t. infection with 1×10<sup>6</sup> yeast cells of <i>P. bra...
<p>Mice (n = 12/group) were infected i.n. with 10<sup>4</sup> PFU of V<sub>K627</sub> (▪), rV<sub>K6...
<p>Representative lung sections from WT and 5-LO<sup>−/−</sup> mice infected with <i>H. capsulatum</...
<p>TNF-α neutralization leads to increased influx of activated cells to the lungs, increased mortali...
<p>BALB/c mice (seven/group) were infected with 1x10<sup>6</sup> of <i>P</i>. <i>brasiliensis</i> ye...
<p>Lung slices from naïve mice were cultured in the absence or presence of LPS (10 μg/ml) for 2, 18 ...
<p>(A) Alveolar macrophages were isolated from untreated WT and <i>Spred-2<sup>−/−</sup></i> mice (n...
<p>Lung levels of TNF-α (A and B), IL-1β (C and D) and IL-6 (E and F) of wild type (WT, black bars) ...
<p>BALB/c mice (seven/group) were infected with <i>P</i>. <i>brasiliensis yeast</i> (1x10<sup>6</sup...
<p>Male BALB/c mice (n = 5 mice/group for each analyses per experiment replicate) were inoculated wi...
<p>(A) Groups of 3–4 mice from the indicated strains were infected intranasally with 6,000 CFU of LV...
<p>Cells were obtained from mice at 7 and 14 days after i.t. injection of PBS or 5×10<sup>5 </sup><i...
<p>Amount of TNF-α in the lungs of 4–6 weeks (A) und 19 months (B) old BALB/c mice after infection w...
<p>WT and iNOS<sup>−/−</sup> mice (n = 6–7) were treated with anti-TNF-α mAb (MP6 XT 22, i.p. inject...
<p>IL12p70 (A), IFN-γ (B), TNF-α (C), IL-10 (D) and IL-4 (E) were quantified in 100 mg of lung homog...
<p>(<b>A, B</b>) At week 2 and 8 after i.t. infection with 1×10<sup>6</sup> yeast cells of <i>P. bra...
<p>Mice (n = 12/group) were infected i.n. with 10<sup>4</sup> PFU of V<sub>K627</sub> (▪), rV<sub>K6...
<p>Representative lung sections from WT and 5-LO<sup>−/−</sup> mice infected with <i>H. capsulatum</...
<p>TNF-α neutralization leads to increased influx of activated cells to the lungs, increased mortali...
<p>BALB/c mice (seven/group) were infected with 1x10<sup>6</sup> of <i>P</i>. <i>brasiliensis</i> ye...
<p>Lung slices from naïve mice were cultured in the absence or presence of LPS (10 μg/ml) for 2, 18 ...
<p>(A) Alveolar macrophages were isolated from untreated WT and <i>Spred-2<sup>−/−</sup></i> mice (n...
<p>Lung levels of TNF-α (A and B), IL-1β (C and D) and IL-6 (E and F) of wild type (WT, black bars) ...
<p>BALB/c mice (seven/group) were infected with <i>P</i>. <i>brasiliensis yeast</i> (1x10<sup>6</sup...
<p>Male BALB/c mice (n = 5 mice/group for each analyses per experiment replicate) were inoculated wi...
<p>(A) Groups of 3–4 mice from the indicated strains were infected intranasally with 6,000 CFU of LV...