Involvement of WREs in the enhancer activity.

<p>A) Schematic representation of reporter plasmids containing substitution(s) in WRE1 and/or WRE2 (RNF43-int2-mut1, RNF43-int2-mut2, and RNF43-int2-mut1+2). B, C) Wild type or mutant reporter plasmids were transfected in HCT116 (B) and SW480 (C) cells, and luciferase activities were measured in triplicate (mean ± standard deviation, *; P<0.05, **; P<0.01, Dunnett’s test).