Fitness of MAPK mutants in <i>C. albicans</i> in gut colonization.

<p>Competition colonization assays with MAPK mutants. CFUs from each individual are represented as open red circles (CAF2-dTOM2) or green symbols (mutant-GFP). Colored lines reflect the tendency of the median of the respective strain. Oral antibiotic therapy (streptomycin, bacitracin and gentamicin) was given to mice (n = 4–6) from 4 days before a gavage of 10⁷ cells in a 1 1 mixture of CAF2-dTOM2 and mutant-GFP (day 0). CFUs were counted and associated with each strain based on their pattern of fluorescent protein expression on solid SD plates. Mutants assessed were A) <i>cek1</i> (diamonds), B) <i>mkc1</i> (squares), C) <i>hog1</i> (triangles) and D) <i>pbs2</i> (inverted triangles).