Improved resistance in Treg-depleted BALB/c DEREG mice in the absence of granulocytes.

<p>BALB/c (white bars), BALB/c DEREG (black bars), C57BL/6 (light grey bars), and C57BL/6 DEREG (dark grey bars) mice were treated with DT on 3 consecutive days starting one day before <i>S. ratti</i> infection. <b>A:</b> Percentage of Gr1⁺CD11b⁺ cells in PBL was analyzed at the indicated time points. <b>BC:</b> BALB/c (white bars), BALB/c DEREG (black bars) were treated with DT and received an additional injection of anti-Gr1 mAb or isotype control one day before <i>S. ratti</i> infection. Percentage of Gr1⁺CD11b⁺ cells in PBL of infected non-depleted mice was measured on day 1 p.i. (<b>B</b>) and number of adult parasitic females in the small intestine was counted on day 6 p.i. (<b>C</b>). Shown are the combined results of two independent experiments (n = 6). Asterisks indicate significant difference of the mean analyzed by students <i>t</i> test (* p≤0.05).