The effect of WT and mutant ADAM12-L on cell growth and migration.

<p>(A) Doubling times of MCF10A cells with stable overexpression of WT or mutant ADAM12-L proteins, or control empty vector (EV)-transduced cells. The data are shown as means with 95% confidence intervals based on 3 independent determinations. (B) Cells were analyzed for migration using Transwell assays. Representative images of crystal violet-stained cells present at the lower face of the Transwell inserts are shown. (C) Quantification of the migration assay. The numbers of migrated cells were counted in five random fields for each insert. The data are shown as mean ± SEM from 3 determinations. *, <i>P</i><0.05.