Impaired mitochondrial oxygen consumption and ATP production in skeletal muscle of HFD-induced obese mice.

<p>A and B, Relative oxygen consumption rate of state IV (B) and state III (A) in isolated mitochondria challenged by glutamate/malate and ADP. The rates in normal diet (ND) group was normalized to 1.00. n = 6 mice for each group. C, Respiratory control ratios (ratio of oxygen consumption rate of state III/state IV) in ND and HFD-induced mice. n = 10 mice for each group. D, Relative cellular ATP content in skeletal muscle from ND and HFD-induced mice. The ATP content in ND group was normalized to 1.00. n = 9 mice for each group. *, P<0.05 compared to ND.