<p>(a) Concentration dependent ligand displacement of three odorants predicted as ligands for the PPARγ receptor. (b) Transcriptional activation of PPARγ by three odorants. Results are shown as the average ± standard deviation of 2 individual experiments with each of the experiments performed with 8 replicas. Activation is given as fold activation relative to the DMSO vehicle. Rosiglitazone (not shown) was used as positive control.</p
<p>A. Heat map showing the expression of genes in the PPARα signature across 332 biosets. Biosets we...
<p>(A) A representative recording of the fluo-3 calcium responses evoked by a 10-s pulse of indicate...
(a-b) Illustration for our model of binding of odor molecules to olfactory receptors and the activat...
<p>PPAR activation induced by <i>(A)</i> the δ-selective agonist GW0742; <i>(B)</i> the pan-agonist ...
<p>A competitive binding assay was used to assess the ability of experimental compounds, FMOC or ros...
<p>A. Known activators of PPARα. B. Activation of PPARα by novel chemicals. Novel activators of PPAR...
<p>(<b>A</b>) MCF-7 cells were transiently transfected with a reporter construct containing the huma...
<p>In mammals, the perception of smell starts with the activation of odorant receptors (ORs) by vola...
The powerful and selective PPARδ agonist, GW 501516 (18), was used as a lead compound for new compou...
<p>(<b>A</b>) HEK-293 cells, transiently transfected with a human PPARγ expression plasmid, a lucife...
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription fac...
<p>n.d. not detected up to 30 µM.</p><p>HEK-293 cells transiently co-transfected with the respective...
<p>A. Summary of PPARα activation or suppression. The PPARα signature was compared to ~1850 biosets ...
<p>(<b>A</b>) GST pull-down assays performed with GST-SRC1<sub>597–791</sub> and [<sup>35</sup>S]-la...
The comprehensive understanding of the precise mode of action and/or adverse outcome pathway (MoA/AO...
<p>A. Heat map showing the expression of genes in the PPARα signature across 332 biosets. Biosets we...
<p>(A) A representative recording of the fluo-3 calcium responses evoked by a 10-s pulse of indicate...
(a-b) Illustration for our model of binding of odor molecules to olfactory receptors and the activat...
<p>PPAR activation induced by <i>(A)</i> the δ-selective agonist GW0742; <i>(B)</i> the pan-agonist ...
<p>A competitive binding assay was used to assess the ability of experimental compounds, FMOC or ros...
<p>A. Known activators of PPARα. B. Activation of PPARα by novel chemicals. Novel activators of PPAR...
<p>(<b>A</b>) MCF-7 cells were transiently transfected with a reporter construct containing the huma...
<p>In mammals, the perception of smell starts with the activation of odorant receptors (ORs) by vola...
The powerful and selective PPARδ agonist, GW 501516 (18), was used as a lead compound for new compou...
<p>(<b>A</b>) HEK-293 cells, transiently transfected with a human PPARγ expression plasmid, a lucife...
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription fac...
<p>n.d. not detected up to 30 µM.</p><p>HEK-293 cells transiently co-transfected with the respective...
<p>A. Summary of PPARα activation or suppression. The PPARα signature was compared to ~1850 biosets ...
<p>(<b>A</b>) GST pull-down assays performed with GST-SRC1<sub>597–791</sub> and [<sup>35</sup>S]-la...
The comprehensive understanding of the precise mode of action and/or adverse outcome pathway (MoA/AO...
<p>A. Heat map showing the expression of genes in the PPARα signature across 332 biosets. Biosets we...
<p>(A) A representative recording of the fluo-3 calcium responses evoked by a 10-s pulse of indicate...
(a-b) Illustration for our model of binding of odor molecules to olfactory receptors and the activat...