<p>(<b>A</b>) GST pull-down assays performed with GST-SRC1<sub>597–791</sub> and [<sup>35</sup>S]-labeled wild-type PPARα in the presence of vehicle (DMSO), OEA (1 μM), CC7 (1 μM), CC12 (1 μM) and GW7647 (1 μM). The percentage of precipitated PPARα proteins with respect to input was quantified. The columns represent the mean ± SEM of at least three experiments, and the data were analyzed by Student’s t test. **P<0.01 and ***P<0.001 compared to SRC1 interaction in presence of vehicle alone. (<b>B</b>) Ligand-dependent interaction profiles of PPARα-RXRα heterodimers with co-activators on DNA. Combined gel shift and super-shift experiments were performed with wild type PPARα-RXRα protein and [<sup>32</sup>P]-labeled human CPT1-PPRE. PPARα-RXRα...
Peroxisome proliferator-activated receptors (PPARs) have been intensively studied as drug targets to...
<p>(A) Forced expression of PPARα preferentially activates the major direction of the PPRE in primar...
Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they r...
The PPARs are integral parts of the RXR-dependent signaling networks. Many other nuclear receptor su...
In this study we report the behavior of two PPAR enantiomeric ligands (R-1 and S-1). Cell-based repo...
In this study we report the behavior of two PPAR enantiomeric ligands (R-1 and S-1). Cell-based repo...
<p>(<b>A</b>) MCF-7 cells were transiently transfected with a reporter construct containing the huma...
Members of the Peroxisome Proliferator Activated Receptor, PPAR, subfamily of nuclear receptors disp...
The heterodimeric complex between retinoic X receptor alpha (RXRα) and peroxisome proliferator-activ...
Abstract Top Background Members of the Peroxisome Proliferator Activated Receptor, PPAR, subfamily o...
16 páginas, 4 figuras -- PAGS nros. 237-252Transcription factors of the peroxisome proliferator-acti...
The study of absorption, distribution, metabolism and excretion (ADME) of compounds within the body ...
ABSTRACT: Peroxisome proliferator-activated receptor α (PPARα) and liver X receptor α (LXRα) are mem...
Nuclear receptors (NRs) activate transcription of target genes in response to binding of ligands to ...
In this study we report the behavior of two PPAR enantiomeric ligands (R-1 and S-1). Cell-based repo...
Peroxisome proliferator-activated receptors (PPARs) have been intensively studied as drug targets to...
<p>(A) Forced expression of PPARα preferentially activates the major direction of the PPRE in primar...
Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they r...
The PPARs are integral parts of the RXR-dependent signaling networks. Many other nuclear receptor su...
In this study we report the behavior of two PPAR enantiomeric ligands (R-1 and S-1). Cell-based repo...
In this study we report the behavior of two PPAR enantiomeric ligands (R-1 and S-1). Cell-based repo...
<p>(<b>A</b>) MCF-7 cells were transiently transfected with a reporter construct containing the huma...
Members of the Peroxisome Proliferator Activated Receptor, PPAR, subfamily of nuclear receptors disp...
The heterodimeric complex between retinoic X receptor alpha (RXRα) and peroxisome proliferator-activ...
Abstract Top Background Members of the Peroxisome Proliferator Activated Receptor, PPAR, subfamily o...
16 páginas, 4 figuras -- PAGS nros. 237-252Transcription factors of the peroxisome proliferator-acti...
The study of absorption, distribution, metabolism and excretion (ADME) of compounds within the body ...
ABSTRACT: Peroxisome proliferator-activated receptor α (PPARα) and liver X receptor α (LXRα) are mem...
Nuclear receptors (NRs) activate transcription of target genes in response to binding of ligands to ...
In this study we report the behavior of two PPAR enantiomeric ligands (R-1 and S-1). Cell-based repo...
Peroxisome proliferator-activated receptors (PPARs) have been intensively studied as drug targets to...
<p>(A) Forced expression of PPARα preferentially activates the major direction of the PPRE in primar...
Nuclear receptors are multi-domain transcription factors that bind to DNA elements from which they r...