Activation of PPARα by diverse chemicals.

<p>A. Known activators of PPARα. B. Activation of PPARα by novel chemicals. Novel activators of PPARα identified in the screen are shown. C. Activation of PPARα by TCDD. (Left) Activation of PPARα by TCDD in Balb/c but not C3H or CBA mice at 4 or 40 μg/kg TCDD (from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112655#pone.0112655.ref047" target="_blank">47</a>]). (Right) Expression behavior of PPARα-regulated genes in wild-type and AhR-null mice after exposure to TCDD. Significantly different from corresponding control: * p < 0.05, **p < 0.01. Significantly different between controls in wild-type and nullizygous mice: ^# p < 0.05, ^## p < 0.01.