In moDCs, active and repressive miRNAs are associated with H3K4me3 and H3K27me3 modification, respectively.

<p>(<b>A</b> and <b>B</b>) Proportion of moDCs-associated miRNAs with H3K4me3 or H3K27me3 modification. High, miRNAs with remarkable H3K4me3 or H3K27me3 modification; low, miRNAs with less H3K4me3 or H3K27me3 modification; no, miRNAs without H3K4me3 or H3K27me3 modification. (<b>C</b>) Repressive miRNAs with H3K27me3 modification. (<b>D</b>) Proportion of moDCs associated miRNAs with both H3K4me3 and H3K27me3 modification (Both). MoDCs were generated and visualized with anti-CD14, anti-CD83, anti-CD11c, anti-CD86, anti-CD80, anti-CD40 and anti-CD11b <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090231#pone.0090231-Huang1" target="_blank">[27]</a>. The gene structure was downloaded from the UCSC Genome Brower. Enriched regions were found in the UCSC Genome Browser (<a href="http://genome.ucsc.edu" target="_blank">http://genome.ucsc.edu</a>.). Histone modification peaks were detected by CHIPOTle. miRNA positions were predicted by Ensembl. The definitive and putative miRNA TSSs were inferred from <a href="http://mirstart.mbc.nctu.edu.tw/browse.php" target="_blank">http://mirstart.mbc.nctu.edu.tw/browse.php</a>. PTSS, putative transcription start site; DTSS, definitive transcription start site.