<p>(A) A heat map showing the profile of relative fitness represented as selection coefficient (<i>s</i>) for each variant during viral replication <i>in vitro</i>. Color indicates the fitness of each mutant calculated as <i>‘s’</i> relative to WT (Materials and method). Red represents positive <i>‘s’</i> (<i>i.e.</i> increased fitness) and blue represents negative <i>‘s’</i>. <i>s</i> = 0 means the same fitness as the WT virus. The secondary structure of the mutated region is annotated below the figure (open circles: solvent exposed residues; filled circles: buried residues; half-filled circles: partially buried residue). (B) Selection coefficient (<i>s</i>) of individual point mutations (relative to WT) calculated from 5 rounds of selecti...
Measuring fitness with precision is a key issue in evolutionary biology, particularly in studying mu...
<p>Relative fitness of all mutants evaluated as a function of database frequency of the amino acid f...
<p>The relative fitness was determined between the T242N mutant and the NI (A and B) and NA (C and D...
<p>(A) Plot of HIV-1 fitness values for CA mutants with the location of the mutation arranged on the...
<p>(A) Plot of fitness HIV-1 for library CA-mutants, overlayed with the Shannon entropy values for e...
(A) Deep mutational scanning selection scheme: each mutant NP influenza library was subjected to sel...
<p>(A) Viability of all CA mutant clones at 35°C (this excludes nonsense mutations, duplicates, fram...
<p>(A) Example of heteroduplex tracking assay (HTA) gel used to measure the viral fitness of PPT Δne...
Empirical knowledge of the fitness effects of mutations is important for understanding many evolutio...
Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address ...
(A) The probability of infection of virions carrying different codons, color coded by the amino acid...
<p>A) The resolution of our assay was assessed by performing 64 competitions of wild-type spores fro...
<p><b>A:</b> A two dimensional slice of the <i>Γ</i> dimensional FL. Fitness values are shown in gra...
Illustration of fitness landscapes for Different ω: A. Functional dependence growth rate vs number o...
<p>A) The 6 wildtype replicates that are cultured on MT4 T-cells show a linear increase in fitness. ...
Measuring fitness with precision is a key issue in evolutionary biology, particularly in studying mu...
<p>Relative fitness of all mutants evaluated as a function of database frequency of the amino acid f...
<p>The relative fitness was determined between the T242N mutant and the NI (A and B) and NA (C and D...
<p>(A) Plot of HIV-1 fitness values for CA mutants with the location of the mutation arranged on the...
<p>(A) Plot of fitness HIV-1 for library CA-mutants, overlayed with the Shannon entropy values for e...
(A) Deep mutational scanning selection scheme: each mutant NP influenza library was subjected to sel...
<p>(A) Viability of all CA mutant clones at 35°C (this excludes nonsense mutations, duplicates, fram...
<p>(A) Example of heteroduplex tracking assay (HTA) gel used to measure the viral fitness of PPT Δne...
Empirical knowledge of the fitness effects of mutations is important for understanding many evolutio...
Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address ...
(A) The probability of infection of virions carrying different codons, color coded by the amino acid...
<p>A) The resolution of our assay was assessed by performing 64 competitions of wild-type spores fro...
<p><b>A:</b> A two dimensional slice of the <i>Γ</i> dimensional FL. Fitness values are shown in gra...
Illustration of fitness landscapes for Different ω: A. Functional dependence growth rate vs number o...
<p>A) The 6 wildtype replicates that are cultured on MT4 T-cells show a linear increase in fitness. ...
Measuring fitness with precision is a key issue in evolutionary biology, particularly in studying mu...
<p>Relative fitness of all mutants evaluated as a function of database frequency of the amino acid f...
<p>The relative fitness was determined between the T242N mutant and the NI (A and B) and NA (C and D...