<p>(A) Example of heteroduplex tracking assay (HTA) gel used to measure the viral fitness of PPT Δnef mutants. Migration of heteroduplexes produced in single or dual/competitive infections are shown on the left and right sides of the panel, respectively. (B) Relative fitness values of PPT and Δnef mutants compared with NL4-3.</p
<p><b>(A)</b> A schematic illustrating how a non-preexisting mutant, A’B’, fully resistant to a comb...
(A) Frequencies of mutations among different egg-passaged seasonal H3N2 vaccine strains are shown as...
<p>HeLa (A) or A549 (B) cells were infected with CVB3 for 40 serial passages (x-axis) and virus prog...
<p>A) The 6 wildtype replicates that are cultured on MT4 T-cells show a linear increase in fitness. ...
<p>(A) A heat map showing the profile of relative fitness represented as selection coefficient (<i>s...
<p>The relative fitness was determined between the T242N mutant and the NI (A and B) and NA (C and D...
<p>(a) A flow chart illustrating how the competition assay was performed. For each competition cultu...
<p>The relative fitness of viruses presenting a mutation at site 177, 186 or at both sites is compar...
<p>In panel (a), the y-axis depicts viral replication fitness (VRC) of c...
We describe a sensitive, internally controlled method for comparing the genetic adaptability and rel...
<p>A) Net growth rates of individual <i>gag</i> viruses in competitions. B) Net growth rate differen...
Comparative mutational robustness of VPg (dark grey) and eIF4E (light gray). Box plots display of th...
<p>(A) Infectivities of JR-FL wt and indicated point mutant envs were determined by titration of vir...
<p>(A) Correlations of log<sub>10</sub> relative frequency of individual point mutations between rep...
<p><b>(A)</b> Immunofluorescence and growth kinetics of recombinant virus carrying the 3’UTR of a va...
<p><b>(A)</b> A schematic illustrating how a non-preexisting mutant, A’B’, fully resistant to a comb...
(A) Frequencies of mutations among different egg-passaged seasonal H3N2 vaccine strains are shown as...
<p>HeLa (A) or A549 (B) cells were infected with CVB3 for 40 serial passages (x-axis) and virus prog...
<p>A) The 6 wildtype replicates that are cultured on MT4 T-cells show a linear increase in fitness. ...
<p>(A) A heat map showing the profile of relative fitness represented as selection coefficient (<i>s...
<p>The relative fitness was determined between the T242N mutant and the NI (A and B) and NA (C and D...
<p>(a) A flow chart illustrating how the competition assay was performed. For each competition cultu...
<p>The relative fitness of viruses presenting a mutation at site 177, 186 or at both sites is compar...
<p>In panel (a), the y-axis depicts viral replication fitness (VRC) of c...
We describe a sensitive, internally controlled method for comparing the genetic adaptability and rel...
<p>A) Net growth rates of individual <i>gag</i> viruses in competitions. B) Net growth rate differen...
Comparative mutational robustness of VPg (dark grey) and eIF4E (light gray). Box plots display of th...
<p>(A) Infectivities of JR-FL wt and indicated point mutant envs were determined by titration of vir...
<p>(A) Correlations of log<sub>10</sub> relative frequency of individual point mutations between rep...
<p><b>(A)</b> Immunofluorescence and growth kinetics of recombinant virus carrying the 3’UTR of a va...
<p><b>(A)</b> A schematic illustrating how a non-preexisting mutant, A’B’, fully resistant to a comb...
(A) Frequencies of mutations among different egg-passaged seasonal H3N2 vaccine strains are shown as...
<p>HeLa (A) or A549 (B) cells were infected with CVB3 for 40 serial passages (x-axis) and virus prog...