Cardiac specific, conditional knockout of the WT RyR2 allele results in markedly reduced RyR2 expression.
- Yingjie Liu (317210)
- Ruiwu Wang (553674)
- Bo Sun (177052)
- Tao Mi (553675)
- Jingqun Zhang (553676)
- Yongxin Mu (553677)
- Ju Chen (297511)
- Michael J. Bround (553678)
- James D. Johnson (176795)
- Anne M. Gillis (553679)
- S. R. Wayne Chen (553680)
Publication date
April 2014
DOIAbstract
<p>Whole heart homogenates were prepared from iRyR2<sup>flox/flox</sup> (A) and iRyR2<sup>flox/Ex3-del</sup> (B) mice before and after tamoxifen treatment, and used for immunoblotting analysis using antibodies against RyR2 or β-actin. Note that the expression of RyR2 in iRyR2<sup>flox/flox</sup> hearts (n = 6) or iRyR2<sup>flox/Ex3-del</sup> hearts (n = 6) was significantly reduced 12 days post tamoxifen treatment (*<i>P</i><0.001).</p
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