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Reduced RyR2 protein expression in heterozygous RyR2 Ex3-del mutant hearts.

  • Yingjie Liu (317210)
  • Ruiwu Wang (553674)
  • Bo Sun (177052)
  • Tao Mi (553675)
  • Jingqun Zhang (553676)
  • Yongxin Mu (553677)
  • Ju Chen (297511)
  • Michael J. Bround (553678)
  • James D. Johnson (176795)
  • Anne M. Gillis (553679)
  • S. R. Wayne Chen (553680)
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Publication date
April 2014
Icon DOI
10.1371/journal.pone.0095615.g005

Abstract

<p>(A) Whole heart homogenates were prepared from wild type (WT) (n = 4) and RyR2 Ex3-del<sup>−/−</sup> mutant (n = 4) mice (2–3 months) and used for immunoblotting analysis using antibodies against RyR2 or β-actin. (B) The expression of RyR2 in the Ex3-del hearts was significantly reduced (58±3%) as compared to that in WT hearts (*<i>P</i><0.001).</p

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