<p>Gray lines correspond to anti-EBLV-1 antibody seroprevalence in each subpopulation over 50 years. Black lines correspond to seroprevalence measured at the end of May. The parameter values used are: <i>R</i><sub>0</sub> = 3, <i>r</i> = 0.6, interisland exchange = 3 individuals, immune-period duration = 6 months, and the default values reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095610#pone-0095610-t002" target="_blank">Table 2</a> for the incubation- and immune-period durations. Abbreviations are as given in the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0095610#pone-0095610-g003" target="_blank">Figure 3</a>.</p
a) The simulation is executed without any control measure, and the number of infected individuals is...
<p>Vaccine Effectiveness (VE) as measured in the case-control study of Misegades et al [<a href="htt...
<p>*New parameters in the model (also described in the main text); all others are as reported in Mar...
<p>Gray shading around the seroprevalence curve represents 95% confidence intervals of model to data...
<p>A: cumulative incidence (total number of symptomatic cases) over a 28-year simulation as a functi...
<p>Sixty parameterizations of strain-transcending immunity (strength and duration) were simulated. W...
<p>Seroprevalence (seropositive fraction, any serotype) from Mérida, Yucatán was recorded in 2014 (6...
(A) The observed (dots) and expected (line) number of cases reported annually. Shaded area represent...
<p>A: Mean number of PfEMP1 variants by age. Black circles: true means per age group in 2005. Black ...
<p>Comparison of our parameter estimates and previously published estimates of <i>R</i>, from studie...
SummaryA major goal of systems biology is the development of models that accurately predict response...
Measurable levels of immunoglobulin G antibodies develop after infections with and vaccinations agai...
A major goal of systems biology is the development of models that accurately predict responses to pe...
Values shown reflect medians across 1,000 simulations drawing parameters from across the set of part...
The persistence of the long-term immune response induced by the heterologous Ad26.ZEBOV, MVA-BN-Filo...
a) The simulation is executed without any control measure, and the number of infected individuals is...
<p>Vaccine Effectiveness (VE) as measured in the case-control study of Misegades et al [<a href="htt...
<p>*New parameters in the model (also described in the main text); all others are as reported in Mar...
<p>Gray shading around the seroprevalence curve represents 95% confidence intervals of model to data...
<p>A: cumulative incidence (total number of symptomatic cases) over a 28-year simulation as a functi...
<p>Sixty parameterizations of strain-transcending immunity (strength and duration) were simulated. W...
<p>Seroprevalence (seropositive fraction, any serotype) from Mérida, Yucatán was recorded in 2014 (6...
(A) The observed (dots) and expected (line) number of cases reported annually. Shaded area represent...
<p>A: Mean number of PfEMP1 variants by age. Black circles: true means per age group in 2005. Black ...
<p>Comparison of our parameter estimates and previously published estimates of <i>R</i>, from studie...
SummaryA major goal of systems biology is the development of models that accurately predict response...
Measurable levels of immunoglobulin G antibodies develop after infections with and vaccinations agai...
A major goal of systems biology is the development of models that accurately predict responses to pe...
Values shown reflect medians across 1,000 simulations drawing parameters from across the set of part...
The persistence of the long-term immune response induced by the heterologous Ad26.ZEBOV, MVA-BN-Filo...
a) The simulation is executed without any control measure, and the number of infected individuals is...
<p>Vaccine Effectiveness (VE) as measured in the case-control study of Misegades et al [<a href="htt...
<p>*New parameters in the model (also described in the main text); all others are as reported in Mar...