Effects on DPO-1 on the spontaneous firing activity of GABAergic preoptic neurons from GAD65-GFP and Kv4.2−/−;GAD65-GFP mice.

<p>A. Cell-attached recordings showing spontaneous firing activity in control, during DPO-1 (0.5 µM) application, and during washout from a GAD65-GFP (A) and a Kv4.2−/−;GAD65-GFP (B) GABAergic neuron. C. Bar chart summarizing the maximum effect of DPO-1 (0.5 µM) and mephetyl tetrazole (0.5 µM) on the firing rate of GABAergic preoptic neurons from GAD65-GFP (n = 8 and n = 5 neurons, respectively) and Kv4.2−/−;GAD65-GFP mice (n = 12 and n = 7 neurons, respectively). ** represents significant differences between GAD65-GFPand Kv4.2−/−;GAD65-GFP groups P<0.01 (ANOVA).