<p>Values are means of two to five experiments ± standard deviation.</p>†<p>ND, not determined.</p><p>*Percent of inhibition at 32 and 10 µM: 18±0.8 and 6.5±0.7%, respectively.</p
<p>Horizontal bars show the mean values of percentage inhibition in each of three groups. The data s...
<p>The effect of DTDA on the indicated enzymes was determined as in <a href="http://www.plosntds.org...
<p>A) CGP-74514A, B) P2, C) P6, D) P7, E) P8 compared to no inhibitor (gray squares) or no enzyme (g...
<p><sup>*</sup>Values are means of at least three experiments. <sup>†</sup>Compounds were tested in ...
<p>(A) Percent inhibition of NDM-1 activity in the presence of 30 uM individual compounds. Data are ...
<p>(<b>A</b>) Inhibition potencies of the candidate compounds. The magnitudes of inhibition by compo...
<p>Inhibition percentage of compounds (12b, 12d, 12e, 12i, 12j and 12k) at 10 µm dose in the full pa...
<p>AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; NMDA, N-methyl-D-aspartic acid. Negat...
<p>nd: no data mean (SD), n = 3</p><p>Inhibition % and dissociation constant (Kd).</p
The data are expressed as mean ± standard error of two independent experiments.</p
<p>TOP: scattergram of percent inhibition data from all plates in the Genzyme HTS. Green: 100% inhib...
<p>Bars indicate the difference between the percentage inhibition observed using 0.11 mM GAL as subs...
<p>The number of compounds found to demonstrate inhibition at 10μM overall and with respect to the t...
<p>(A) Activity of HCHT on MU-NAG<sub>2</sub> substrate as a function of substrate concentration. (B...
<p><sup>a</sup> The percentage inhibition was measured under the concentration of 100 μM. <sup>b</su...
<p>Horizontal bars show the mean values of percentage inhibition in each of three groups. The data s...
<p>The effect of DTDA on the indicated enzymes was determined as in <a href="http://www.plosntds.org...
<p>A) CGP-74514A, B) P2, C) P6, D) P7, E) P8 compared to no inhibitor (gray squares) or no enzyme (g...
<p><sup>*</sup>Values are means of at least three experiments. <sup>†</sup>Compounds were tested in ...
<p>(A) Percent inhibition of NDM-1 activity in the presence of 30 uM individual compounds. Data are ...
<p>(<b>A</b>) Inhibition potencies of the candidate compounds. The magnitudes of inhibition by compo...
<p>Inhibition percentage of compounds (12b, 12d, 12e, 12i, 12j and 12k) at 10 µm dose in the full pa...
<p>AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; NMDA, N-methyl-D-aspartic acid. Negat...
<p>nd: no data mean (SD), n = 3</p><p>Inhibition % and dissociation constant (Kd).</p
The data are expressed as mean ± standard error of two independent experiments.</p
<p>TOP: scattergram of percent inhibition data from all plates in the Genzyme HTS. Green: 100% inhib...
<p>Bars indicate the difference between the percentage inhibition observed using 0.11 mM GAL as subs...
<p>The number of compounds found to demonstrate inhibition at 10μM overall and with respect to the t...
<p>(A) Activity of HCHT on MU-NAG<sub>2</sub> substrate as a function of substrate concentration. (B...
<p><sup>a</sup> The percentage inhibition was measured under the concentration of 100 μM. <sup>b</su...
<p>Horizontal bars show the mean values of percentage inhibition in each of three groups. The data s...
<p>The effect of DTDA on the indicated enzymes was determined as in <a href="http://www.plosntds.org...
<p>A) CGP-74514A, B) P2, C) P6, D) P7, E) P8 compared to no inhibitor (gray squares) or no enzyme (g...