<p>During CDAA diet administration, mRNA expression levels of collagen I, collagen IV, TIMP, TGF-β, and αSMA were significantly increased in the livers of <i>Nrd1<sup>+/+</sup></i> mice but not in those of <i>Nrd1<sup>−/−</sup></i> mice. Those factors were not altered by administration of the CSAA diet in <i>Nrd1<sup>+/+</sup></i> or <i>Nrd1<sup>−/−</sup></i> mice. *<i>P</i><0.05.</p
<p>(A) The effects of LY2405319 administration on MCD diet-induced liver fibrosis in mice. H&E stain...
<p>A) The total degree of liver injury (hepatic steatosis and necroinflammation) was determined acco...
<p>CCl<sub>4</sub> treatment of <i>CCL3<sup>−/−</sup></i> mice lead to significantly altered express...
<p>A. Serum ALT was not elevated in both <i>Nrd1<sup>+/+</sup></i> and <i>Nrd1<sup>−/−</sup></i> mic...
<p>A. Liver fibrosis was determined by Sirius red staining (red) in <i>Nrd1<sup>+/+</sup></i> and <i...
<p>A. mRNA of TNF-α was slightly increased in both <i>Nrd1<sup>+/+</sup></i> (significantly) and <i>...
<p>A. Immunohistochemistry showed that TNF-α protein (red, arrowheads) was expressed in F4/80-positi...
<p>A. Immunostainings for αSMA demonstrated that activated myofibroblasts were detected in <i>Nrd1<s...
<p>A. Histology of the livers of <i>Nrd1<sup>+/+</sup></i> and <i>Nrd1<sup>−/−</sup></i> mice fed th...
<p>A. A liver fragment was divided into two pieces. One was directly subjected to protein extraction...
<p><b>(A)</b> Histological analysis on Sirius Red stained livers revealed a progressive collagen dep...
<p>Liver specimens were obtained and the total RNA was extracted from male wild type or <i>Tet-mev-1...
<p>A. Masson’s trichrome–stained liver sections from mice fed (a) the control diet+pLV-shNC, (b) the...
<p>A. Steatosis was observed in both <i>Nrd1<sup>+/+</sup></i> and <i>Nrd1<sup>–/–</sup></i> mice af...
<p>(A) Gene expression levels of the fibrotic makers alpha-smooth muscle actin (<i>αSMA</i>), collag...
<p>(A) The effects of LY2405319 administration on MCD diet-induced liver fibrosis in mice. H&E stain...
<p>A) The total degree of liver injury (hepatic steatosis and necroinflammation) was determined acco...
<p>CCl<sub>4</sub> treatment of <i>CCL3<sup>−/−</sup></i> mice lead to significantly altered express...
<p>A. Serum ALT was not elevated in both <i>Nrd1<sup>+/+</sup></i> and <i>Nrd1<sup>−/−</sup></i> mic...
<p>A. Liver fibrosis was determined by Sirius red staining (red) in <i>Nrd1<sup>+/+</sup></i> and <i...
<p>A. mRNA of TNF-α was slightly increased in both <i>Nrd1<sup>+/+</sup></i> (significantly) and <i>...
<p>A. Immunohistochemistry showed that TNF-α protein (red, arrowheads) was expressed in F4/80-positi...
<p>A. Immunostainings for αSMA demonstrated that activated myofibroblasts were detected in <i>Nrd1<s...
<p>A. Histology of the livers of <i>Nrd1<sup>+/+</sup></i> and <i>Nrd1<sup>−/−</sup></i> mice fed th...
<p>A. A liver fragment was divided into two pieces. One was directly subjected to protein extraction...
<p><b>(A)</b> Histological analysis on Sirius Red stained livers revealed a progressive collagen dep...
<p>Liver specimens were obtained and the total RNA was extracted from male wild type or <i>Tet-mev-1...
<p>A. Masson’s trichrome–stained liver sections from mice fed (a) the control diet+pLV-shNC, (b) the...
<p>A. Steatosis was observed in both <i>Nrd1<sup>+/+</sup></i> and <i>Nrd1<sup>–/–</sup></i> mice af...
<p>(A) Gene expression levels of the fibrotic makers alpha-smooth muscle actin (<i>αSMA</i>), collag...
<p>(A) The effects of LY2405319 administration on MCD diet-induced liver fibrosis in mice. H&E stain...
<p>A) The total degree of liver injury (hepatic steatosis and necroinflammation) was determined acco...
<p>CCl<sub>4</sub> treatment of <i>CCL3<sup>−/−</sup></i> mice lead to significantly altered express...