Effects of chronic treatments with anticonvulsants lamotrigine and topiramate on behavior of <i>Gria1−/−</i> mice.

<p>Cumulative locomotor activities of <i>Gria1−/−</i> and WT mice treated chronically with lamotrigine- or topiramate-supplemented chow for 5-min time intervals (<b>A, C</b>) and for the whole 2-h experiment (<b>B, D</b>). Data are means ± SEM (n = 8–27). In <b>A</b> and <b>C</b>, the earliest significant point from the control activity has been marked by ^#(<i>p</i><0.05). Topiramate treatment reduced the time spent in open arms of elevated-plus maze (<b>E</b>; means ± SEM, n = 9–12) and increased immobility time in forced swimming test (<b>F</b>; means ± SEM, n = 11–12) in <i>Gria1−/−</i> mice. **<i>p</i><0.01, ***<i>p</i><0.001 for the difference between genotypes after the same treatment; ^#<i>p</i><0.05, ^###<i>p</i><0.001 for the difference from the control within the same genotype (two-way ANOVA followed by Bonferroni <i>post-hoc</i> test).