Effects of pregnenolone, haloperidol and clozapine on activities of WT and DAT KO mice in the open field.

<p>Baseline activities were monitored over 30 min, the mice were injected (i.p.) with vehicle, or 30 or 60 mg/kg pregnenolone (Preg) and returned immediately to the open field for 2 h. Cumulative distance traveled (A), vertical activity (B), and stereotypical activities (B) are shown. (D–F) Cumulative post-injection activities after WT and DAT KO mice were administered (i.p.) vehicle, 0.2 mg/kg haloperidol (HAL), 2.0 mg/kg clozapine (CLZ), or 60 mg/kg Preg, and monitored for locomotor (D), rearing (E), and stereotypical (F) activities. N = 9–15 mice/genotype/treatment condition, ^a<i>p</i><0.05, WT-Veh versus KO-Veh; ^b<i>p</i><0.05, within groups versus Veh; ^c<i>p</i><0.05, within groups HAL or CLZ versus Preg60.