Expression of gp38 in synovial tissues.

<p><b>(A)</b> IHC immunoperoxidase labelling of gp38 expression in normal, OA and RA tissues. RA CTRL: IgG1 isotype control. Lining and sublining areas, and a large lymphoid aggregate centered by a HEV (arrows) are shown. Bar: 50 µm. Original magnification 400x <b>(B)</b> Changes in gp38 expression after anti-TNF therapy. Representative imunoperoxidase labeling of gp38 of a single patient pre- and post-treatment. Bar: 100 µm. Original magnification 200x <b>(C)</b> Mean±SD gp38 immunostained fractional area in the different groups (OA vs RA Mann Whitney test *p<0.0001), and in basal (Pre) and post-anti-TNF-α therapy (Post) in 16 patients (RA Pre vs RA Post Wilcoxon matched-pairs signed rank test *p<0.0001).