LPS-induced rapid reduction of BCL6 levels does not occur in MyD88^−/− TRIF^−/− mice.

<p>WT or MyD88^−/− TRIF^−/− mice were <i>i.p.</i> injected with LPS. <i>(A)</i> Representative FACS plots (n = 4) showing CD11c and I-A/E expression on splenic cells in 0 h or 24 h post-LPS injected mice. <i>(B)</i> and <i>(C)</i> The MFI±SEM (n = 4) of CD11c <i>(B)</i> and CD86 <i>(C)</i> in gated splenic CD11c^int I-A^hi cells obtained from either WT or MyD88^−/− TRIF^−/− mice 0 h (black bar) or 24 h after (grey bar) LPS injection. <i>(D)</i> and <i>(E)</i> The average MFI ±SEM (n = 4) of BCL6 in CD11c^hi I-A^int<i>(D)</i> and CD11c^int I-A^hi<i>(E)</i> cells 0 h (black bar) and 24 h after (grey bar) LPS injection. ***<i>p</i><0.001 (two way ANOVA) was compared within each group.