The Pearson correlation between structural/functional connectivity indices (x axis) and clinical markers (y axis) of pair-wise subregions within the DMN of RRMS patients.

<p>The functional connectivity (FC) value (a) between the PCC/PCUN and the right mTL negatively correlated with the PASAT in RRMS patients (P<0.05, Bonferroni corrected). The EDSS score negatively correlated with the log (N track) of the tract between the PCC/PCUN and the left IPL (b) and negatively correlated with the FA value of the tract between the PCC/PCUN and the left mTL (c) in RRMS patients (P<0.05, Bonferroni corrected). The EDSS score positively correlated with the MD value of the tract between the MPFC and the left IPL (d) in RRMS patients (P<0.05, Bonferroni corrected). The PASAT score positively correlated with the FA value of the tract between the PCC/PCUN and the right IPL (e) in RRMS patients (P<0.05, Bonferroni corrected). The MFIS score negatively correlated with the MD values of the tract between the MPFC and the left IPL (f) in RRMS patients (P<0.05, Bonferroni corrected). The BPF score positively correlated with the FA value of the tract between the MPFC and the left IPL (g) in RRMS patients (P<0.05, Bonferroni corrected). The BPF score positively correlated with the volume of the tract between the PCC/PCUN and the MPFC (h) in RRMS patients (P<0.05, Bonferroni corrected). The BPF score positively correlated with the log (N track) value between the PCC/PCUN and the left mTL (i) in RRMS patients (P<0.05, Bonferroni corrected). AD = axial diffusivity, EDSS = expanded disability status scale, FA = fractional anisotropy, IPL = inferior parietal lobule, MD = mean diffusivity, mTL = medial temporal lobes, MPFC = medial prefrontal cortex, PASAT = paced auditory serial addition test, PCC/PCUN = posterior cingulate cortex/precuneus, RRMS = relapsing–remitting multiple sclerosis, TWMLL = total white matter lesion loads.