The DMN exhibits divergent connectivity properties across chronic pain patient groups.

<p>(<b>A</b>) Brain maps show the group average spatial representaion of the DMN for all groups (average map thresholed at z-score >4.0). CBP and CRPS patients show decreased MPFC and increased PreCu and left and right LP representaion within the DMN compared to healthy subjects. (<b>B</b>) Maps illustrate clusters of significantly different connectivity for the DMN using a whole-brain voxelwise ANOVA (mixed effects analysis, f-zscore >3.0, corrected for multiple comparisons by cluster threshold p<0.01). All patient groups show decreased connectivity in MPFC (F_3,78 = 7.21, p<0.001), ACC (F_3,78 = 10.77, p<0.001), and left anterior INS/IFG (F_3,78 = 9.13, p<0.001). CBP and CRPS subjects display increased connectivity in PreCu (F_3,78 = 5.64, p<0.01), compared to healthy controls and OA patients, and in right LP (F_3,78 = 5.70, p<0.01) compared to healthy controls. In addition, the left SMG exhibits stronger negative connectivity in CRPS and OA groups, than in CBP and control subjects (F_3,78 = 9.57, p<0.001). Bars represent mean ± S.E.M. of normalized connectivity strength (Post hoc test: *p<0.05 vs healthy; †p<0.05 vs CBP; ‡p<0.05 vs CRPS; #p<0.05 vs OA).