Electrostatic potential surface of the human ABCC6 model with the predicted substrate binding sites (boxed).

<p>(A) EPS for open conformation ABCC6 model, (B) EPS for closed conformation ABCC6 model. (C, D) EPD of substrate binding site(s) in open and closed conformation respectively. Electronegative potential scale of −10 kcal/mol to +10 kcal/mol is shown. Blue, red and white colors represent positively, negatively and neutrally charged areas respectively.