<p>Potential maps are generated for cis-N-acetyl bound (A) CDK2 (B) CDK5 (C) CDK2:L83C mutant, and (D) CDK2:H84D mutant. Red and blue represent electronegative and electropositive potentials, respectively. The inhibitor is also shown.</p
The rational development of specific inhibitors for 500 protein kinases encoded in the human genome ...
<p>The ATP binding site was shown in green on cyclin dependent kinase 2 (CDK2) (grey), commonly refe...
<p>For clarity, only the inhibitors and the adjacent protein residues are shown: (A) cis-OH bound CD...
(A) Electrostatic potential (red, negative potential; blue, positive potential) on the surface of th...
<p>(A) CDK2 bound with cis-OH (green) and cis-N-acetyl (red); (B) similar CDK5 complexes. Residue-le...
Publicación ISIWe report a theoretical study on a series of CDK2 inhibitors using a set of global re...
Publicación ISIWe report a theoretical study on a series of CDK2 inhibitors using a set of global re...
<p>Results are shown for (A) CDK2 and (B) CDK5 complexes. Highly fluctuating regions are labelled: (...
The rational development of specific inhibitors for the 500 protein kinases encoded in the human gen...
<p>(A) CDK2/cyclinE complex, (B) CDK5/p25 complex, (C) cis-OH or cis-N-acetyl inhibitor, and (D) tra...
<p>Electrostatic potential map indicates the assembly and disassembly of C-site in presence of NAD<s...
We have used a chemically diverse panel of kinase inhibitors to assess the chemical similarity of th...
The rational development of specific inhibitors for the ~500 protein kinases encoded in the human ge...
The rational development of specific inhibitors for the ~500 protein kinases encoded in the human ge...
<p>(A) EPS for open conformation ABCC6 model, (B) EPS for closed conformation ABCC6 model. (C, D) EP...
The rational development of specific inhibitors for 500 protein kinases encoded in the human genome ...
<p>The ATP binding site was shown in green on cyclin dependent kinase 2 (CDK2) (grey), commonly refe...
<p>For clarity, only the inhibitors and the adjacent protein residues are shown: (A) cis-OH bound CD...
(A) Electrostatic potential (red, negative potential; blue, positive potential) on the surface of th...
<p>(A) CDK2 bound with cis-OH (green) and cis-N-acetyl (red); (B) similar CDK5 complexes. Residue-le...
Publicación ISIWe report a theoretical study on a series of CDK2 inhibitors using a set of global re...
Publicación ISIWe report a theoretical study on a series of CDK2 inhibitors using a set of global re...
<p>Results are shown for (A) CDK2 and (B) CDK5 complexes. Highly fluctuating regions are labelled: (...
The rational development of specific inhibitors for the 500 protein kinases encoded in the human gen...
<p>(A) CDK2/cyclinE complex, (B) CDK5/p25 complex, (C) cis-OH or cis-N-acetyl inhibitor, and (D) tra...
<p>Electrostatic potential map indicates the assembly and disassembly of C-site in presence of NAD<s...
We have used a chemically diverse panel of kinase inhibitors to assess the chemical similarity of th...
The rational development of specific inhibitors for the ~500 protein kinases encoded in the human ge...
The rational development of specific inhibitors for the ~500 protein kinases encoded in the human ge...
<p>(A) EPS for open conformation ABCC6 model, (B) EPS for closed conformation ABCC6 model. (C, D) EP...
The rational development of specific inhibitors for 500 protein kinases encoded in the human genome ...
<p>The ATP binding site was shown in green on cyclin dependent kinase 2 (CDK2) (grey), commonly refe...
<p>For clarity, only the inhibitors and the adjacent protein residues are shown: (A) cis-OH bound CD...
DOI
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