ASO binding to the SOD-1 minigene mRNA transcribed and spliced in the nuclear extract.

<p>The binding profile of the ASOs to mRNA transcribed and spliced in the nuclear extract (blue line) compared with the mRNA in denatured extract (orange line). The proteins bound to the mRNA at each ASO target site are listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101752#pone.0101752.s001" target="_blank">Figure S1</a>. Here, proteins bound are listed below the ASO number by class: RNA-binding proteins (R), E-complex proteins (E), H-complex proteins (H) and exon-junction proteins (EJ). ASO binding is reported as percent untreated mRNA control. The mean and errors reported are based on three trials.