Effect of increased TF expression on formation of FVIIa-AT complex in HTF mice administered with therapeutic concentrations of rFVIIa.

<p>HTF mice were injected with LPS (5 mg/kg body weight) intraperitoneally. 5 h after LPS administration, rFVIIa (120 µg/kg body weight) was injected into these mice as well as unchallenged mice. 1 h following rFVIIa administration, blood was drawn from these mice by cardiac puncture, and plasma samples were processed for isolation of TF microparticles or determination of FVIIa-AT levels. (A) Microparticle TF activity; (B) FVIIa-AT levels (n = 4). The concentration of FVIIa-AT (ng/ml) reflects ng of FVIIa complexed with AT. *Indicates the values differ in statistically significant manner between the control and LPS-treated mice.