<p>100 randomly selected successful realizations in gray, mean of all successful realizations in black, Eq. 19 (expectation from new mutation) in red, Eq. 10 (expectation from standing variation) in blue. Ticks on X-axis represent observed (black) and predicted (red) <i>t<sub>min</sub></i> (Eq. 21) while ticks on the Y-axis represents observed (black) and predicted (red) <i>N<sub>min</sub></i> (Eq. 22). A) <i>N<sub>0</sub></i> = 10,000, <i>r</i> = 0.01, <i>s</i> = 0.02, <i>u</i> = 10<sup>−5</sup> B) <i>N<sub>0</sub></i> = 100,000, <i>r</i> = 0.005, <i>s</i> = 0.015, <i>u</i> = 10<sup>−6</sup>; 10,000 realizations.</p
<p>Solid curves and points show the probability of fixation of a mutation as a function of its selec...
<p>For each human gene, the expected number of mutations is obtained based on the normal mutation pa...
<p>(<b>A</b>) Waterfall distribution of colony sizes, according to median values (standard method). ...
<p>100 randomly selected successful realizations in gray, mean of all successful realizations in bla...
Analytical predictions (lines) and outcomes of multi-locus simulations (symbols) of the averaged num...
<p>The standing genetic variation plays a greater role in rescue when <i>p</i><sub>0</sub> > <i>u/r<...
<p>3D plots comparing the total emergence probability of a mutated strain with feedbacks (denoted <i...
<p>The results shown are for the diploid method with , for peak 0 (a, left) and peak 1 (b, right). I...
<p>The open circles give the expectation of the stationary distribution and the closed squares give ...
<p>orange: sweep from standing variation blue: sweep from a new mutation, blue: neutral model a: A c...
<p>For each combination of <i>U</i> ( = 0.1, 0.3, and 0.5) and <i>s</i> ( = 0.01 and 0.1), simulatio...
<p>This schematic shows the fates (“fix”, fixation; “ext” extinction) of mutations with different se...
<p>The fitnesses are chosen from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.po...
<p>In the main figure the amplification factor of the fittest phenotype is: 5 (blue curve), 10, (gr...
<p>The probability that resistance is detected for the first time in the first, second or third year...
<p>Solid curves and points show the probability of fixation of a mutation as a function of its selec...
<p>For each human gene, the expected number of mutations is obtained based on the normal mutation pa...
<p>(<b>A</b>) Waterfall distribution of colony sizes, according to median values (standard method). ...
<p>100 randomly selected successful realizations in gray, mean of all successful realizations in bla...
Analytical predictions (lines) and outcomes of multi-locus simulations (symbols) of the averaged num...
<p>The standing genetic variation plays a greater role in rescue when <i>p</i><sub>0</sub> > <i>u/r<...
<p>3D plots comparing the total emergence probability of a mutated strain with feedbacks (denoted <i...
<p>The results shown are for the diploid method with , for peak 0 (a, left) and peak 1 (b, right). I...
<p>The open circles give the expectation of the stationary distribution and the closed squares give ...
<p>orange: sweep from standing variation blue: sweep from a new mutation, blue: neutral model a: A c...
<p>For each combination of <i>U</i> ( = 0.1, 0.3, and 0.5) and <i>s</i> ( = 0.01 and 0.1), simulatio...
<p>This schematic shows the fates (“fix”, fixation; “ext” extinction) of mutations with different se...
<p>The fitnesses are chosen from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.po...
<p>In the main figure the amplification factor of the fittest phenotype is: 5 (blue curve), 10, (gr...
<p>The probability that resistance is detected for the first time in the first, second or third year...
<p>Solid curves and points show the probability of fixation of a mutation as a function of its selec...
<p>For each human gene, the expected number of mutations is obtained based on the normal mutation pa...
<p>(<b>A</b>) Waterfall distribution of colony sizes, according to median values (standard method). ...