Pathways affected by genes downregulated in the CA1 region.

<p>624 genes downregulated in the CA1 subregion of rTg4510 were subjected subjected to Ingenuity Pathway Analysis. The top axis represents the –log(p-value) of the probability that the gene set represented the canonical pathway by chance, as determined by the Fisher’s Exact Test, with the red line delineating p = 0.05 threshold, and the bottom axis represents the ratio of the number of genes from the query gene set in the canonical pathway to the total number of genes in the pathway. The top canonical pathways significantly overrepresented by these genes, shown by the blue bars, included pathways implicated in neurodegeneration, neuronal signaling and cell migration. The green bars show that these genes also significantly overlap with synaptic transmission modules affected in AD <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106050#pone.0106050-Zhang1" target="_blank">[14]</a>. The query genes in these pathways are shown in Table S8 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106050#pone.0106050.s003" target="_blank">File S1</a>.