Gene network analysis of differentially expressed transcripts between mESC-derived Hb9 control and A2 SMA MNs.

<p>Ingenuity Pathways Analysis (IPA) of biological functions for transcripts (<b>A</b>) upregulated or (<b>B</b>) downregulated in A2 SMA MNs compared to Hb9 control MNs. IPA of canonical pathways for transcripts (<b>C</b>) upregulated or (<b>D</b>) downregulated in A2 SMA MNs compared to Hb9 control MNs. IPA was performed on upregulated or downregulated transcripts with at least a 2-fold change and a p value less than or equal to 0.05. The top 7 canonical pathways or biological functions were shown in the bar graphs. The top canonical pathway for (<b>E</b>) upregulated (Transcriptional Networks in ESCs) or (<b>F</b>) downregulated (Notch Signaling) transcripts in A2 SMA MNs compared to Hb9 control MNs. Downregulated transcripts are green while the upregulated transcripts are red.