Ingenuity Pathway Analysis (IPA) of genes expressed differentially in ESCs and NCs and targeted by nFGFR1 only.

<p>Top biological functions, networks and diseases identified. Networks illustrate the degree of gene upregulation (red) and downregulation (green) by color intensity. Genes that were bound by nFGFR1 and not differentially regulated according to our cut-off are displayed in gray. Solid lines represent direct, and dotted lines indirect, interactions between genes in the network. A complete interpretation of network shapes and interactions can be found in Material and Methods. P-values were calculated using the right-tailed Fisher’s exact test. <b>(A-C)</b> nFGFR1 binding to genes in ESCs: <b>(A)</b> biological functions and diseases; <b>(B)</b> top network controlling cell proliferation and survival; and <b>(C)</b> eight top canonical pathways. <b>(D-F)</b> Binding of nFGFR1 to genes in in RA-differentiated NCs: (<b>D)</b> biological functions and diseases; <b>(E)</b> networks; and <b>(F)</b> eight top canonical pathways.