PbICP is essential for parasite development <i>in vivo</i>.
- Christine Lehmann (207801)
- Anna Heitmann (251465)
- Satish Mishra (622854)
- Paul-Christian Burda (394976)
- Mirko Singer (622855)
- Monica Prado (622856)
- Livia Niklaus (622857)
- Céline Lacroix (622858)
- Robert Ménard (12385)
- Friedrich Frischknecht (149269)
- Rebecca Stanway (622859)
- Photini Sinnis (149539)
- Volker Heussler (207821)
Publication date
August 2014
DOIAbstract
<p><i>In vivo</i> infectivity of <i>pbicp</i>-parasites was determined by parasite prepatency. Mice (5–10 per treatment group) were infected with 5×10<sup>3</sup> PbICP<sub>control</sub>, PbICP<sub>cond</sub>, PbICP<sub>KO</sub>, or PbICP<sub>comp</sub> salivary gland sporozoites by intravenous (i.v.) inoculation. The onset of a blood stage infection (prepatency) was determined by observation of blood smears up to 20 days post-infection. Non-infected mice were not considered in the prepatency calculations.</p><p>PbICP is essential for parasite development <i>in vivo</i>.</p
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