Pluripotent stem cells are significantly more hypermethylated than their corresponding parental cells.

<p>(A) Distribution of 485,577 CpG sites with their methylation scores in the parental cells, iPSCs and ESCs. (B) The average number of CpG sites with low (0–0.3), middle (0.3–0.7) and high (0.7–1.0) methylation. The iPSCs have more highly methylated sites than the parental cells.