IL-17 deficient mice exhibit more severe acute colitis following DSS administration.

<p>IL-17KO mice and WT controls were given 1.5% DSS in drinking water or water alone for 7 days followed by consumption of water alone. Colitis severity was assessed by weight loss (A), colon length (day 10) (B) and H&E histology (day 0 and 10) (Calibration bar = 200 µm) (C). Colon barrier permeability was assessed on day 10 by detection of FITC-dextran serum (D). The results are expressed as mean values ± SEM for each geneotype in A (n = 5–6), B (n = 10), C (n = 2), and D (n = 5). *p<0.05; **p<0.01.