PTP1B^−/− mice are resistant to DSS-induced colitis.

<p>A) The colon tissue of WT and PTP1B^−/− mice that received either control water or water containing 2.5% DSS for 2 weeks. B) Representative H&E-stained mouse distal colonic sections on day 8 after treatment. C) Disease activity index after the beginning DSS treatment. D) The survival rate of mice during the course of DSS treatment. E-F) The relative activity of MPO (E) and the labeling with anti-F4/80 antibody (F) in colon from mice treated with or without DSS (on day 8). G) Serum cytokine concentrations in WT and PTP1B^−/− mice after 8 days of DSS treatment. Data are representative of 3 replicated experiments that produced similar results (n = 6 per group per condition). *, <i>p</i><0.05, **, <i>p</i><0.01.