Inhibition of dextran sulphate sodium (DSS)-induced acute colitis in CD69-deficient (CD69 KO) mice.

<p>Acute colitis was induced by giving animals 4% DSS in drinking water for 7 days, followed by normal drinking water. (A) The survival rates of CD69 KO and wild-type (WT) mice after the initiation of during DSS-induced acute colitis. The survival was recorded daily (n = 10 per group). (B, C) Changes in the disease activity index (B) and body weight (%) (C) over the course of DSS treatment in CD69 KO and WT mice. The data are presented as the means (SD) (n = 10 per group). *p<0.01. Three independent experiments were performed with similar results.